5-hydroxy-6-<wbr/>methoxy (S)-<wbr/>Duloxetine

5-hydroxy-6-methoxy (S)-Duloxetine

CAT N°: 28127
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396.00 336.60

5-hydroxy-6-methoxy (S)-Duloxetine is a metabolite of (S)-duloxetine (Item No. 14317).{48296,47342} It is formed from (S)-duloxetine via a 5- or 6-hydroxy duloxetine intermediate, which is formed by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2D6, and a catechol duloxetine intermediate.{47342} 5-hydroxy-6-methoxy (S)-Duloxetine binds to the serotonin (5-HT), norepinephrine, and dopamine transporters with Ki values of 266, 920, and 2,814 nM, respectively.

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