5'-Ethynyl-2'<wbr/>-deoxy<wbr/>cytidine

5′-Ethynyl-2′-deoxycytidine

CAT N°: 11581
Price:

48.00 40.80

5′-Ethynyl-2′-deoxycytidine (EdC) is a nucleoside analog that inhibits replication of the herpes simplex virus-1 (HSV-1) KOS strain (ID50 = 0.2 ?g/mL).{36600} It also reduces virus-induced cytopathogenicity of HSV-1, HSV-2, and vaccinia virus strains in PRK cells (MICs = 0.2-0.4, 1-2, and 5 ?g/ml, respectively).{36599} EdC is an inhibitor of thymidylate synthetase, selectively reducing DNA incorporation of [1′,2′-3H]deoxyuridine over [CH3-3H]deoxythymidine in PRK cells (ID50s = 3 and 120 ?g/ml, respectively). It inhibits thymidine synthetase in and reduces proliferation of L1210 cells, an effect which is reversed by addition of deoxythymidine (ID50s = 4.4 and 1,000 ?g/ml, respectively). EdC has been used to monitor DNA synthesis and cellular replication via click chemistry conjugation of the ethynyl group to an azido group of various fluorochromes.{36601}

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