5-<wbr/>Chlorouracil

5-Chlorouracil

CAT N°: 27790
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5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil (Item No. 26088). In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic.{46329} Uracil is chlorinated at the 5 position in a cell-free myeloperoxidase, peroxide, and chloride system in which hypochlorous acid is formed.{46330} 5-Chlorouracil has been found in human neutrophils stimulated with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in vitro and in inflammatory human exudate isolated from sites of superficial infection. Levels of 5-chlorouracil are increased in exudate isolated from the site of inflammation in a rat model of carrageenan-induced inflammation and in patient-derived human atherosclerotic aortic tissue.{46331,46332}

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