Histone H2A (Xenopus, recombinant)
Histone H2A (Xenopus, recombinant)
Histone H2A is a core histone that forms a dimer with histone H2B.{46631} Two histone H2A/H2B dimers form an octameric...
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![5-Butyl-4-<wbr/>[2,3-difluoro-<wbr/>4-(phenyl<wbr/>methoxy)<wbr/>phenyl]-6-<wbr/>phenyl-2-<wbr/>pyrimidinamine](https://www.bertin-bioreagent.com/wp-content/uploads/2024/07/31338.png "5-Butyl-4-<wbr/>[2,3-difluoro-<wbr/>4-(phenyl<wbr/>methoxy)<wbr/>phenyl]-6-<wbr/>phenyl-2-<wbr/>pyrimidinamine")
From €66.00 €56.10
5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC50s = 66 and 2,730 nM for the human and mouse enzymes, respectively).{52747} It is selective for mPGES-1 over COX-1 but does inhibit COX-2 at 20 µM. It also inhibits LPS-induced prostaglandin E2 (PGE2; Item No. 14010) production in mouse peritoneal cells (IC50 = 12 nM). In vivo, 5-butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine (25 mg/kg) reduces carrageenan-induced paw edema in rats.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 250 µg, 500 µg |
|---|---|
| Shipping | dry ice |
| CAS number | 2253745-78-5 |
| Molecular formula | C27H25F2N3O |
| Smiles | NC1=NC(C2=CC=C(OCC3=CC=CC=C3)C(F)=C2F)=C(CCCC)C(C4=CC=CC=C4)=N1 |
| Molecular weight | 445,5 |
| Custom code | 2933.59 |
| Formulation | A solution in methyl acetate |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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Histone H2A is a core histone that forms a dimer with histone H2B.{46631} Two histone H2A/H2B dimers form an octameric...
Sirtuin 5 (SIRT5) is an enzyme that catalyzes the NAD-dependent removal of malonyl, succinyl, and glutaryl groups from target proteins.{55107,55108}...
This mixture contains the primary metabolites of prostaglandins (PGs) D2, E2, and F2?. Contents: 13,14-dihydro-15-keto PGD2, 13,14-dihydro-15-keto PGE2, 11?-PGF2?, 13,14-dihydro-15-keto...
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![5-Butyl-4-<wbr/>[2,3-difluoro-<wbr/>4-(phenyl<wbr/>methoxy)<wbr/>phenyl]-6-<wbr/>phenyl-2-<wbr/>pyrimidinamine](https://www.bertin-bioreagent.com/wp-content/uploads/2023/06/logo-visa.png "5-Butyl-4-<wbr/>[2,3-difluoro-<wbr/>4-(phenyl<wbr/>methoxy)<wbr/>phenyl]-6-<wbr/>phenyl-2-<wbr/>pyrimidinamine"){kind=logo}
![5-Butyl-4-<wbr/>[2,3-difluoro-<wbr/>4-(phenyl<wbr/>methoxy)<wbr/>phenyl]-6-<wbr/>phenyl-2-<wbr/>pyrimidinamine](https://www.bertin-bioreagent.com/wp-content/uploads/2023/06/logo-mastercard.png "5-Butyl-4-<wbr/>[2,3-difluoro-<wbr/>4-(phenyl<wbr/>methoxy)<wbr/>phenyl]-6-<wbr/>phenyl-2-<wbr/>pyrimidinamine"){kind=logo}
![5-Butyl-4-<wbr/>[2,3-difluoro-<wbr/>4-(phenyl<wbr/>methoxy)<wbr/>phenyl]-6-<wbr/>phenyl-2-<wbr/>pyrimidinamine](https://www.bertin-bioreagent.com/wp-content/uploads/2023/06/logo-discover.png "5-Butyl-4-<wbr/>[2,3-difluoro-<wbr/>4-(phenyl<wbr/>methoxy)<wbr/>phenyl]-6-<wbr/>phenyl-2-<wbr/>pyrimidinamine"){kind=logo}
![5-Butyl-4-<wbr/>[2,3-difluoro-<wbr/>4-(phenyl<wbr/>methoxy)<wbr/>phenyl]-6-<wbr/>phenyl-2-<wbr/>pyrimidinamine](https://www.bertin-bioreagent.com/wp-content/uploads/2023/06/logo-american-express.png "5-Butyl-4-<wbr/>[2,3-difluoro-<wbr/>4-(phenyl<wbr/>methoxy)<wbr/>phenyl]-6-<wbr/>phenyl-2-<wbr/>pyrimidinamine"){kind=logo}
