405,00 SAR

405,00 SAR

CAT N°: 16979
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From 89.00 75.65

SAR405 is an inhibitor of the phosphoinositide 3-kinase (PI3K) class III isoform Vps34 (IC50 = 1.2 nM).{27429} It is without effect (IC50 > 10,000 nM) on other PI3K isoforms and mTOR. SAR405 alters vesicle trafficking and inhibits autophagy by blocking autophagosome formation.{27429} SAR405 also synergizes with the mTOR inhibitor everolimus (Item No. 11597) in preventing the proliferation of renal tumor cell lines.{27429}

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