4-<wbr/>pentynoyl-<wbr/>Coenzyme A (trifluoroacetate salt)

4-pentynoyl-Coenzyme A (trifluoroacetate salt)

CAT N°: 10547
Price:

From 111.00 94.35

Protein acetylation is a reversible, post-translational modification regulated by lysine acetyltransferases and deacetylases and plays a key role in regulating gene expression. 4-pentynoyl-Coenzyme A (trifluoroacetate salt) (4-pentynoyl-CoA (trifluoroacetate salt)) is an alkyne-derivatized acetyl-CoA reporter that enables rapid detection of acetylated proteins in vitro.{18193} As an acyl-CoA donor, the 4-pentynoyl analog is metabolically transferred onto lysine residues of proteins by lysine acetyltransferases. An azide-alkyne bioconjugation reaction, known as click chemistry, can then be used to readily tag acetylated proteins with fluorescent or biotinylated labels for subsequent analysis.{17991}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • S-4-pentynoate coenzyme A, trifluoroacetate salt
  • Correlated keywords
    • 50347-32-5 click chemistry proteins acetylation posttranslational post-translational post translational modify modification acetyl-CoA acetyl-coenzyme A lysine histons acetyl click-it click it click tag click-tag 14-pentynoyl-coa(adamantyl) indole
  • Product Overview:
    Protein acetylation is a reversible, post-translational modification regulated by lysine acetyltransferases and deacetylases and plays a key role in regulating gene expression. 4-pentynoyl-Coenzyme A (trifluoroacetate salt) (4-pentynoyl-CoA (trifluoroacetate salt)) is an alkyne-derivatized acetyl-CoA reporter that enables rapid detection of acetylated proteins in vitro.{18193} As an acyl-CoA donor, the 4-pentynoyl analog is metabolically transferred onto lysine residues of proteins by lysine acetyltransferases. An azide-alkyne bioconjugation reaction, known as click chemistry, can then be used to readily tag acetylated proteins with fluorescent or biotinylated labels for subsequent analysis.{17991}

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