4-oxo Docosa<wbr/>hexaenoic Acid

4-oxo Docosahexaenoic Acid

CAT N°: 21373
Price:

From 74.00 62.90

4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA (Item No. 90310) with antiproliferative and PPAR? agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 µM, however it increased proliferation of MCF-7 cells.{34687} 4-oxo DHA binds covalently to PPAR? and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 µM.{16872}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4-oxo-5E,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid
  • Correlated keywords
    • 4oxoDHA anti-proliferative peroxisome proliferator activated receptor gamma PPARg MCF10F MDAMB-231 MDAMB231 BT-549? MCF7
  • Product Overview:
    4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA (Item No. 90310) with antiproliferative and PPAR? agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 µM, however it increased proliferation of MCF-7 cells.{34687} 4-oxo DHA binds covalently to PPAR? and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 µM.{16872}

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