4-oxo-27-<wbr/>TBDMS Withaferin A

4-oxo-27-TBDMS Withaferin A

CAT N°: 28323
Price:

From 122.00 103.70

4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A (Item No. 11352) that has anticancer activity.{50042} It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 µM) but not to carboplatin-resistant A2780 (A2780/CP70) cells (IC50 = >100 µM). It is selective for A2780 cells over non-cancerous ARPE19 cells (IC50 = 1,660 µM). 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (5?,6?,22R)-27-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,6-epoxy-22-hydroxy-1,4-dioxo-ergosta-2,24-dien-26-oic acid, ?-lactone
  • Correlated keywords
    • 4oxo27TBDMS 4-oxo27TBDMS 4oxo-27TBDMS 4oxo27-TBDMS A-2780 CP-70 ARPE-19 noncancerous anti-cancer cyto-toxic
  • Product Overview:
    4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A (Item No. 11352) that has anticancer activity.{50042} It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 µM) but not to carboplatin-resistant A2780 (A2780/CP70) cells (IC50 = >100 µM). It is selective for A2780 cells over non-cancerous ARPE19 cells (IC50 = 1,660 µM). 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells.

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