4-Methyl<wbr/>umbelliferyl-<wbr/>?-L-Iduronide 2-sulfate (sodium salt)

4-Methylumbelliferyl-?-L-Iduronide 2-sulfate (sodium salt)

CAT N°: 9001600
Price:

From 322.00 273.70

4-Methylumbelliferyl-?-L-iduronide 2-sulfate (4-MU-?-IdoA 2-sulfate) is a fluorogenic substrate of ?-L-iduronidase that has been used in an assay to detect Hurler syndrome.{33268} It is also used as a substrate for iduronate-2-sulfatase in tests for Hunter disease.{33267,33269} For these latter tests, the initial enzymatic product, 4-MU-?-IdoA (Item No. 19543) can be measured by mass spectrometry, or it can be hydrolyzed with ?-L-iduronidase to liberate the fluorophore 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (2R,3S,4S,5R,6S)-3,4-dihydroxy-6-((4-methyl-2-oxo-2H-chromen-7-yl)oxy)-5-(sulfonatooxy)tetrahydro-2H-pyran-2-carboxylate, disodium salt
  • Correlated keywords
    • 415915-09-2 1045020-74-3 1045348-22-8 4MU MU-?-IdoA 2-sulfate
  • Product Overview:
    4-Methylumbelliferyl-?-L-iduronide 2-sulfate (4-MU-?-IdoA 2-sulfate) is a fluorogenic substrate of ?-L-iduronidase that has been used in an assay to detect Hurler syndrome.{33268} It is also used as a substrate for iduronate-2-sulfatase in tests for Hunter disease.{33267,33269} For these latter tests, the initial enzymatic product, 4-MU-?-IdoA (Item No. 19543) can be measured by mass spectrometry, or it can be hydrolyzed with ?-L-iduronidase to liberate the fluorophore 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.{27251}

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