3,3',5'-<wbr/>Triiodo-L-<wbr/>thyronine

3,3′,5′-Triiodo-L-thyronine

CAT N°: 17598
Price:

From 128.00 108.80

3,3′,5’-Triiodo-L-thyronine, also known as reverse T3 (rT3), is a thyroid hormone generated by deiodination of the prohormone thyroxine. It is about 1,000-fold less active at the thyroid hormone receptors TR? and TR? than 3,3′,5-triiodo-L-thyronine (Item No. 16028) and commonly described as inactive.{28789,28791} However, high serum levels of rT3 are found in neonates and in certain conditions.{28795,28793,28790,28792} It reportedly activates TR??1, a native form of TR? that lacks a nuclear localization signal and functions in the cytoplasm.{28794} Through this action, rT3 initiates actin polymerization, particularly in astrocytes and neurons.{28794}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-L-tyrosine
  • Correlated keywords
    • 2820-50-0 70-39-3 reverse T3 rTc 3,3,5-T3 isoliothyronine triiodothyronine L-triiodothyronine biochemical hormone receptor agonist cytoskeletal research signal transduction endocrinology peptide thyroid variant
  • Product Overview:
    3,3′,5’-Triiodo-L-thyronine, also known as reverse T3 (rT3), is a thyroid hormone generated by deiodination of the prohormone thyroxine. It is about 1,000-fold less active at the thyroid hormone receptors TR? and TR? than 3,3′,5-triiodo-L-thyronine (Item No. 16028) and commonly described as inactive.{28789,28791} However, high serum levels of rT3 are found in neonates and in certain conditions.{28795,28793,28790,28792} It reportedly activates TR??1, a native form of TR? that lacks a nuclear localization signal and functions in the cytoplasm.{28794} Through this action, rT3 initiates actin polymerization, particularly in astrocytes and neurons.{28794}

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