3,3'-Diindolyl<wbr/>methane

3,3′-Diindolylmethane

CAT N°: 15927
Price:

From €48.00 €40.80

3,3’-Diindolylmethane (DIM) is a bioactive metabolite of indole-3-carbinol, a phytochemical produced by the breakdown of the glucosinolate glucobrassicin found in cruciferous vegetables. At 10-30 µM, it demonstrates anticancer and chemopreventative effects involving Nrf2 induction of Phase 2 enzymes, promotion of apoptosis, induction of cell cycle arrest, inhibition of cell proliferation, and inhibition of histone deacetylases and DNA methylation activities.{25951,25954,25953} Furthermore, at 0.3 µM DIM was shown to act as a potent radioprotector and mitigator of the effects of ionizing radiation exposure by stimulating an ATM-driven DNA damage-like response and NF-?B survival signaling in cultured epithelial cells.{25952}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3,3′-methylenebis-1H-indole
  • Correlated keywords
    • phytochemicals indole-3-carbinol indoles 3 three carbinol glucosinolate glucobrassicin cruciferous vegetables broccoli anticancers anti-cancer anti cancers chemoprevention Nrf2 Phase 2 enzymes apoptosis epigenetics radioprotectors radiomitigators antioxidants anti-oxidants oxidants intracellular signaling signals inhibitors inhibits inhibitions epigenetics DNAs damages repairs natural products transduction AhR agonists arundine HBs 236 HB236 HB-236 antiradiation anti-radiation chemopreventative metabolites cells cycles arrests proliferation histones deacetylases methylation Bis(3-indolyl)methane
  • Product Overview:
    3,3’-Diindolylmethane (DIM) is a bioactive metabolite of indole-3-carbinol, a phytochemical produced by the breakdown of the glucosinolate glucobrassicin found in cruciferous vegetables. At 10-30 µM, it demonstrates anticancer and chemopreventative effects involving Nrf2 induction of Phase 2 enzymes, promotion of apoptosis, induction of cell cycle arrest, inhibition of cell proliferation, and inhibition of histone deacetylases and DNA methylation activities.{25951,25954,25953} Furthermore, at 0.3 µM DIM was shown to act as a potent radioprotector and mitigator of the effects of ionizing radiation exposure by stimulating an ATM-driven DNA damage-like response and NF-?B survival signaling in cultured epithelial cells.{25952}

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