3-<wbr/>hydroxy-<wbr/>3-<wbr/>methylglutaryl-<wbr/>Coenzyme A-<wbr/>d<sub>3</sub> (ammonium salt)

3-hydroxy-3-methylglutaryl-Coenzyme A-d3 (ammonium salt)

CAT N°: 9000368
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55.00 46.75

3-hydroxy-3-methylglutaryl-Coenzyme A-d3 is intended for use as an internal standard for the quantification of 3-hydroxy-3-methylglutaryl-coenzyme A (Item No. 25394) by GC- or LC-MS. 3-hydroxy-3-methylglutaryl-Coenzyme A (HMG-CoA) is an intermediate in several metabolic pathways.{42966,15099,37635,20949} Conversion of HMG-CoA to mevalonate by HMG-CoA reductase is the rate-limiting first step in the cholesterol biosynthetic pathway.{37635,15099} Alternatively, HMG-CoA can be cleaved into acetyl-CoA and the ketone body acetoacetate in mitochondria by HMG-CoA lyase.{20949,42966} HMG-CoA is also an intermediate in the degradation of leucine.{20949}

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