3?-Deoxy-3?-<wbr/>fluoro<wbr/>thymidine

3?-Deoxy-3?-fluorothymidine

CAT N°: 36519
Price:

128.00 108.80

3?-Deoxy-3?-fluorothymidine is a nucleoside analog.{61967} It is phosphorylated by thymidine kinase 1 (TK1) but not TK2 and also inhibits TK1 and TK2 (Kis = 6 and 10 µM, respectively). 3?-Deoxy-3?-fluorothymidine inhibits HIV-1 reverse transcriptase (EC50 = 5 nM) and the replication of HIV-1 in MT-4 human T cell leukemia cells (EC50 = 5 nM).{61968} It decreases mitochondrial DNA (mtDNA) levels and the oxygen consumption rate (OCR) and induces upregulation of the cell differentiation marker CD11b in OCI-AML-2 and MV4-11 acute myeloid leukemia (AML) cells in a concentration-dependent manner.{61969} 3?-Deoxy-3?-fluorothymidine (50 mg/kg) reduces tumor growth in an OCI-AML-2 AML mouse xenograft model. A radiolabeled form of 3?-deoxy-3?-fluorothymidine, [18F]FLT, is commonly used as a PET tracer for in vivo imaging of tumors.{61970}

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