3'-Azido-3'-<wbr/>deoxy<wbr/>thymidine ?-D-<wbr/>glucuronide (sodium salt)

3′-Azido-3′-deoxythymidine ?-D-glucuronide (sodium salt)

CAT N°: 18679
Price:

92.00 78.20

3′-Azido-3′-deoxythymidine ?-D-glucuronide is a metabolite of the nucleoside reverse transcriptase inhibitor, zidovudine (Item No. 15492), formed by direct conjugation by UDP-glucuronosyltransferase 2B7.{20875} The azido group of both zidovudine and its glucuronide metabolite can be reduced to an amino group by cytochrome P450 (CYP)3A, CYP2A6, or CYP2B1, forming 3’-amino-3’-deoxythymidine (AMT) and AMT glucuronide, respectively.{30307} Several compounds, including rifampicin (Item No. 14423), valproic acid (Item No. 13033), fluconazole (Item No. 11594), and efavirenz (Item No. 14412) are known to interfere with zidovudine glucuronidation in vitro in human liver microsomes.{30307,30306} Formation of AMT, which is 5-7-fold more toxic than the parent drug, is thought to be enhanced through inhibition of zidovudine glucuronidation.{30307}

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