3-Acetyl<wbr/>aconitine

3-Acetylaconitine

CAT N°: 36155
Price:

43.00 36.55

3-Acetylaconitine is a diterpene alkaloid that has been found in Aconitum and has diverse biological activities.{62673,62674} It is cytotoxic to P388 leukemia cells (IC50 = 18.6 µM).{62673} It inhibits brevetoxin binding to (IC50 = 1.3 µM), and increases free sodium and calcium concentrations in, rat brain synaptosomes. 3-Acetylaconitine (60-100 nM) induces arrhythmia in isolated guinea pig atria.{62674} In vivo, 3-acetylaconitine (100 µg/kg, i.v.) reduces paw licking, flicking, and shaking in a mouse model of formalin-induced inflammatory pain.

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