29951,00 MDL

29951,00 MDL

CAT N°: 16266
Price:

77.00 65.45

NMDA receptors are neuroreceptors that have binding sites for glycine or D-serine as well as L-glutamate.{27735} MDL 29951 is an antagonist of NMDA receptors with high affinity for the glycine binding site (Ki = 140 nM).{27731} It is functional both in vitro and in vivo.{27731} MDL 29951 blocks NMDA receptor-dependent convulsions in audiogenic seizure-susceptible DBA/2J mice.{27731} It is used to evaluate the role of the glycine site of the NMDA receptor in neurological signaling.{27734,27733} MDL 29951 is also an agonist of the G protein-coupled receptor GPR17 (EC50 values range from 7 nM to 6 µM, depending on the assay).{27732} GPR17 is thought to be involved in oligodendrocyte differentiation and myelin formation/repair.{27732}

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