260301,00 SAR

260301,00 SAR

CAT N°: 17391
Price:

From 57.00 48.45

SAR260301 is an inhibitor of phosphatidylinositol 3-kinase (PI3K) isoform ? (IC50 = 52 nM).{34311} It is selective for p110? over other PI3K isoforms.{34311} SAR260301 demonstrates significant in vivo activity in a UACC-62 xenograft model in mice.{34311} It has synergistic antitumor activity when combined with the BRAF inhibitor vemurafenib (PLX4032; Item No. 10618) or the MEK inhibitor selumetinib (AZD 6244; Item No. 11599) in PTEN-deficient/BRAF-mutated human melanoma tumor models.{34310}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-[2-[(2S)-2,3-dihydro-2-methyl-1H-indol-1-yl]-2-oxoethyl]-6-(4-morpholinyl)-4(3H)-pyrimidinone
  • Correlated keywords
    • 1260584-64-2 PI3KB PI3K-B SAR-260301 p110B p110-B UACC62 anti-tumor
  • Product Overview:
    SAR260301 is an inhibitor of phosphatidylinositol 3-kinase (PI3K) isoform ? (IC50 = 52 nM).{34311} It is selective for p110? over other PI3K isoforms.{34311} SAR260301 demonstrates significant in vivo activity in a UACC-62 xenograft model in mice.{34311} It has synergistic antitumor activity when combined with the BRAF inhibitor vemurafenib (PLX4032; Item No. 10618) or the MEK inhibitor selumetinib (AZD 6244; Item No. 11599) in PTEN-deficient/BRAF-mutated human melanoma tumor models.{34310}

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