25(R)-<wbr/>27-<wbr/>hydroxy Cholesterol

25(R)-27-hydroxy Cholesterol

CAT N°: 14790
Price:

From 85.00 72.25

The liver X receptors (LXR? and LXR?) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism.{12040} 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXR? and LXR? in vitro with EC50 values of 85 and 71 nM, respectively, and is a potent suppressor of cholesterol biosynthesis.{13891,23747} 25(R)-27-hydroxy Cholesterol is the more predominant-occurring (~80%) stereoisomer of the endogenous oxysterol 27-hydroxy cholesterol.{23746,23745}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (25R)-cholest-5-ene-3?,26-diol
  • Correlated keywords
    • livers X receptors LXR? LXR? LXRalpha LXRbeta LXR.alpha. LXR.beta. LXRa LXRb LXR-alpha LXR-beta LXR-.alpha. LXR-.beta. LXR-a LXR-b a b alpha beta .beta. .alpha. ? ? oxysterol cholesterol lipids metabolism agonists nuclear receptors atherosclerosis 27-hydroxy cholesterol 26-hydroxy cholesterol CYP27 CYPs CYP-27 27 cholesterols hydroxy 27 26 endogenous agonist fatty acids metabolism activates active potent suppressors steroids oxysterols
  • Product Overview:
    The liver X receptors (LXR? and LXR?) are nuclear hormone receptors whose native ligands, oxysterols, induce the expression of genes involved in cholesterol and fatty acid metabolism.{12040} 27-hydroxy Cholesterol, a sterol 27-hydroxylase-mediated cholesterol hydroxylation product, activates LXR? and LXR? in vitro with EC50 values of 85 and 71 nM, respectively, and is a potent suppressor of cholesterol biosynthesis.{13891,23747} 25(R)-27-hydroxy Cholesterol is the more predominant-occurring (~80%) stereoisomer of the endogenous oxysterol 27-hydroxy cholesterol.{23746,23745}

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