2,4-<wbr/>DPD

2,4-DPD

CAT N°: 71200
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From 28.00 23.80

The pro-angiogenic factor HIF-1? is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-? prolyl hydroxylase (HIF-PH).{8840} 2,4-DPD is a cell permeable, competitive inhibitor of HIF-PH. 2,4-DPD inhibits the hydroxylation of P564 by acting as a competitive inhibitor of the HIF-PH cofactor ?-keto glutarate, with effective concentrations in the low µM range.{9005} 2,4-DPD is therefore expected to act as a pro-angiogenic compound, via the HIF-1? system.{9790,8799}

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