β2-Microglobulin (dog, recombinant)

β2-Microglobulin (dog, recombinant)

CAT N°: 29555
Price:

825.00 701.25

?2-Microglobulin is a 98-amino acid protein and the light chain component of major histocompatibility complex (MHC) class I molecules.{45065,53723} It is non-covalently associated with the MHC class I ? chain and comprises a protein-building subunit of the MHC class I molecule to facilitate complex transport to the cell surface and antigen presentation to cytotoxic T cells. ?2-Microglobulin is found in all nucleated cells, as well as in extracellular fluids, including urine and serum, and MHC class I-associated ?2-microglobulin exhibits dissociation and equilibrium exchange with circulating soluble ?2-microglobulin.{45065,53724} Germline mutations at the ?2-microglobulin exon 1/intron 1 splice site have been found in dog mammary gland simple and complex carcinoma tumor samples.{53725}

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