2'-Deoxy<wbr/>guanosine 5'-mono<wbr/>phosphate (sodium salt hydrate)

2′-Deoxyguanosine 5′-monophosphate (sodium salt hydrate)

CAT N°: 16408
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2′-Deoxyguanosine 5′-monophosphate (dGMP) is used as a substrate of guanylate kinases to generate dGDP, which in turn is phosphorylated to dGTP, a nucleotide precursor used in DNA synthesis. In addition, dGMP can be efficiently phosphorylated by the type I thymidylate kinase of the malarial agent P. falciparum.{26880,26883} In humans, deficiency of mitochondrial deoxyguanosine kinase, which synthesizes dGMP from ATP and deoxyguanosine, contributes to mitochondrial DNA depletion syndrome.{26882,26881}

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