2-deoxy-D-<wbr/>Glucose-<sup>13</sup>C<sub>6</sub>

2-deoxy-D-Glucose-13C6

CAT N°: 34312
Price:

109.00 92.65

2-deoxy-D-Glucose-13C6 is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose (Item No. 14325) by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.{22664,61618} It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate.{22666} 2-deoxy-D-Glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B osteosarcoma cells cultured under hypoxic conditions when used at a concentration of 2 mg/ml.{61619,22663} In vivo, 2-deoxy-D-glucose (500 mg/kg) reduces tumor growth in 143B osteosarcoma and MV522 non-small cell lung cancer mouse xenograft models when used alone or in combination with doxorubicin (Item No. 15007) or paclitaxel (Item No. 10461).{61620}

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