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17-phenyl trinor Prostaglandin F2? amide (17-phenyl trinor PGF2? amide) is an F-series PG analog in which the C-1 carboxyl group has been modified to an unsubstituted amide. PG esters have been shown to have ocular hypotensive activity.{8837} PG N-ethyl amides were recently introduced as alternative PG hypotensive prodrugs.{8941} Although it has been claimed that PG amides are not converted to the free acids in vivo,{8941} studies have shown that bovine and human corneal tissue converts the amides of various PGs to the free acids with a conversion efficiency of about 10-20% relative to the hydrolysis of isopropyl esters.{9311} 17-phenyl trinor PGF2? amide would be expected to show the typical intraocular effects of latanoprost, but with the much slower hydrolysis pharmacokinetics of the PG N-amides.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 155205-89-3 |
| Molecular formula | C23H33NO4 |
| Smiles | O[C@@H]1[C@H](C/C=CCCCC(N)=O)[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1, O[C@@H]1[C@H](C/C=CCCCC(N)=O)[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1, O[C@@H]1[C@H](C/C=CCCCC(N)=O)[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C1 |
| Molecular weight | 387,5 |
| Custom code | 2937.50 |
| Formulation | A solution in ethanol |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
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