17-<wbr/>AAG

17-AAG

CAT N°: 11039
Price:

From 55.00 46.75

17-AAG is an inhibitor of heat shock protein 90 (Hsp90) and a derivative of geldanamycin (Item No. 13355) that selectively inhibits BT474 tumor cell Hsp90 over fibroblast Hsp90 (IC50s = 5 and 943 nM, respectively).{46058} It inhibits the growth of prostate cancer cell lines (IC50s = 25-45 nM) and promotes the degradation of HER2 and induces growth arrest and apoptosis in breast cancer cells overexpressing HER2 (IC50s = 4-72 nM).{20728,20725} In vivo, 17-AAG (25 mg/kg, i.p.) reduces tumor size in a G-415 gallbladder cancer mouse xenograft model.{46059}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 17-demethoxy-17-(2-propenylamino)-geldanamycin
  • Correlated keywords
    • 17AAG 17 AAG inhibitors inhibits inhibition heat shock proteins Hsp-90 geldanamycin cancers breasts HER-2 hepatotoxicity analogs tumors prostate cells apoptosis NSC330507 NSC-330507 BMS722782 BMS-722782 CP127374 CP-127374 KOS-953 KOS953 BT-474 17AAG G415
  • Product Overview:
    17-AAG is an inhibitor of heat shock protein 90 (Hsp90) and a derivative of geldanamycin (Item No. 13355) that selectively inhibits BT474 tumor cell Hsp90 over fibroblast Hsp90 (IC50s = 5 and 943 nM, respectively).{46058} It inhibits the growth of prostate cancer cell lines (IC50s = 25-45 nM) and promotes the degradation of HER2 and induces growth arrest and apoptosis in breast cancer cells overexpressing HER2 (IC50s = 4-72 nM).{20728,20725} In vivo, 17-AAG (25 mg/kg, i.p.) reduces tumor size in a G-415 gallbladder cancer mouse xenograft model.{46059}

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