16-Ketoestradiol

16-Ketoestradiol

CAT N°: 36033
Price:

534.00 453.90

16-Ketoestradiol is an active metabolite of the endogenous estrogen estrone (Item No. 10006485).{60391} It is formed from estrone via an estriol (Item No. 10006484) or a 16-epiestriol (Item No. 33455) intermediate by oxidation of the C-16 hydroxyl. 16-Ketoestradiol binds to estrogen receptor ? (ER?) and ER? with IC50 values of 112.2 and 50.1 nM for the human receptors, respectively.{65163} Intravaginal administration of 16-ketoestradiol increases vaginal epithelial thickness, stratification, and cornification in mice, indicating antiestrogenic activity.{65164}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 3,17?-dihydroxy-estra-1,3,5(10)-trien-16-one
  • Correlated keywords
    • Keto Oxo-estradiol-17? NSC51169 16KE2 ketoE2 ER-? ? C16 anti-estrogenic 16-kE2
  • Product Overview:
    16-Ketoestradiol is an active metabolite of the endogenous estrogen estrone (Item No. 10006485).{60391} It is formed from estrone via an estriol (Item No. 10006484) or a 16-epiestriol (Item No. 33455) intermediate by oxidation of the C-16 hydroxyl. 16-Ketoestradiol binds to estrogen receptor ? (ER?) and ER? with IC50 values of 112.2 and 50.1 nM for the human receptors, respectively.{65163} Intravaginal administration of 16-ketoestradiol increases vaginal epithelial thickness, stratification, and cornification in mice, indicating antiestrogenic activity.{65164}

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