From €182.00 €154.70
The naturally-occurring estrogens are estrone (E1, Item No. 10006485), estradiol (E2, Item No. 10006315), and estriol (E3, Item No. 10006484).{9611} 16?-hydroxy Estrone (16?-OHE1) is a hydroxylated metabolite of E1 as well as an interconversion product with E2.{24474,24473} E1 is 16?-hydroxylated by cytochrome P450 (CYP) isoforms, including CYP1A1, CYP3A5, CYP3A4, and CYP3A7, with CYP3A5 being breast-specific.{24483} 16?-OHE1 is sulphatized or glucuronidated before excretion.{24483} It is increased in rheumatoid arthritis and decreased by physical activity.{24474,24473} Unlike the parent estrogens and other hydroxylated metabolites of E1, 16?-OHE1 binds covalently and persistently activates estrogen receptors.{24475} In addition, this metabolite increases cell proliferation and does not suppress TNF-? secretion, whereas other estrogen metabolites are not pro-proliferative and have marked effects on TNF-? secretion.{24474,24483} The levels of 16?-OHE1 are increased in some forms of hormone therapy.{24472} Because hormone therapy increases breast cancer risk, 16?-OHE1 has been implicated as a risk factor for breast cancer, although supportive data remains elusive.{24476,24483,24472}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 566-76-7 |
| Molecular formula | C18H22O3 |
| Smiles | O=C1[C@H](O)C[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C |
| Molecular weight | 286,4 |
| Custom code | 2907.19 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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