15(S)-<wbr/>Latanoprost

15(S)-Latanoprost

CAT N°: 16818
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15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost. The IC50 values for the free acid forms of latanoprost and 15(S)-latanoprost were determined to be 3.6 nM and 24 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle.{9736} A 3 µg dose of 15(S)-latanoprost caused a 1 mmHg reduction of IOP in normotensive cynomolgus monkeys.{9736} 15(S)-Latanoprost is a potential impurity in most commercial preparations of the latanoprost bulk drug product.

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