15(R)-<wbr/>HETE

15(R)-HETE

CAT N°: 34710
Price:

From 213.00 181.05

15(R)-HETE is a monohydroxy fatty acid. It is produced by aspirin-acetylated COX-2 from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) and converted into the specialized pro-resolving mediator 15(R)-lipoxin A4 (Item No. 90415) and 15(R)-lipoxin B4 in a transcellular process via 5-lipoxygenase (5-LO).{1504,1506,8116,2629,369} It is also produced by the cytochrome P450 (CYP) isoform CYP2C9.{1504,1506,8116,65098} 15(R)-HETE can also be formed from arachidonic acid by COX-1 in stimulated human mast cells and accumulates because, unlike 15(S)-HETE (Item No. 34720), it is not converted to 15-KETE (15-OxoETE; Item No. 34730) by 15-hydroxyprostaglandin dehydrogenase (15-PGDH).{55556} It is an agonist of PPAR?/?, inducing expression of a PPAR?/? target gene in a reporter assay using NIH3T3 cells.{65099}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 15R-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid
  • Correlated keywords
    • 15(R)HETE mono hydroxy COX2 15(R)lipoxin 5LO CPY 450 2C9 15(S)HETE 15KETE 15OxoETE PPAR ? ? NIH 3T3
  • Product Overview:
    15(R)-HETE is a monohydroxy fatty acid. It is produced by aspirin-acetylated COX-2 from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) and converted into the specialized pro-resolving mediator 15(R)-lipoxin A4 (Item No. 90415) and 15(R)-lipoxin B4 in a transcellular process via 5-lipoxygenase (5-LO).{1504,1506,8116,2629,369} It is also produced by the cytochrome P450 (CYP) isoform CYP2C9.{1504,1506,8116,65098} 15(R)-HETE can also be formed from arachidonic acid by COX-1 in stimulated human mast cells and accumulates because, unlike 15(S)-HETE (Item No. 34720), it is not converted to 15-KETE (15-OxoETE; Item No. 34730) by 15-hydroxyprostaglandin dehydrogenase (15-PGDH).{55556} It is an agonist of PPAR?/?, inducing expression of a PPAR?/? target gene in a reporter assay using NIH3T3 cells.{65099}

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