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15,16-Dihydrotanshinone I (DHTS) is a diterpene tanshinone that has been found in the roots of S. miltiorrhiza with diverse biological activities.{39842} DHTS inhibits RHL-2H3 mast cell degranulation with an IC50 value of 14.3 ?M and reduces the tyrosine phosphorylation of phospholipase C?2 (PLC?2) and ERK.{39843} It prevents HuR binding to RNA in a cell-free assay (Ki = 3.74 nM) and inhibits the production of TNF mRNA and protein in MCF-7 cells.{39842} DHTS reduces the viability of MCF-7, MDA-MB-231, and SK-BR-3 breast cancer cells with IC50 values of 0.84, 0.92, and 1.2 ?M, respectively. It also reduces collagen-induced aggregation of washed rabbit platelets (IC50 = 8.7 ?M).{39844} In vivo, DHTS (25 mg/kg per day) reduces tumor growth in an HL-60 leukemia mouse xenograft model by 68% relative to control without decreasing body weight.{39845} In mice with scopolamine-induced learning and memory impairment, DHTS (2-4 mg/kg, p.o.) increases latency to step-through in a passive avoidance test by approximately 3- to 4-fold, and it inhibits acetylcholinesterase in brain homogenate (IC50 = 25 ?M).{39846}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 mg, 25 mg, 5 mg, 50 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 87205-99-0 |
| Molecular formula | C18H14O3 |
| Smiles | O=C(C1=C2C(C(C)=CC=C2)=CC=C1C3=C4[C@@H](C)CO3)C4=O |
| Molecular weight | 278,3 |
| Custom code | 2932.99 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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Proprotein convertase subtilisin kexin 9 (PCSK9) is a member of the subtilisin serine protease family with an important role in...
Secretory phospholipase A2 (sPLA2) (Type IIA) is a calcium-dependent PLA2 superfamily member that is encoded by PLA2G2A in humans.{56210} It...
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CD34 is a transmembrane phosphoglycoprotein and sialomucin protein that is commonly used as a marker for hematopoietic progenitor cells.{59706,59704} It...
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