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15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 (Item No. 14010) formed by 15-hydroxy prostaglandin dehydrogenase (15-PGDH).{2777} Unlike PGE2, 15-keto PGE2 does not bind effectively to the PGE2 receptors EP2 and EP4 expressed in CHO cells (Kis = 2.6 and 15 µM, respectively) or induce adenylate cyclase activity in the same cells (EC50s = 1.8 and >33 µM, respectively). However, it does bind to EP2 and EP4 in HEK cells expressing these receptors (IC50s = 0.117 and 2.82 µM, respectively), as well as induces cAMP formation (EC50s = 0.137 and 0.426 µM, respectively) and the transcriptional activity of ?-catenin/TCF in the same cells.{57866} 15-keto PGE2 inhibits CD3-CD28-MHC-I-induced proliferation of isolated human CD4+ T cells in a concentration-dependent manner.{57867} It also reduces mortality in a mouse model of LPS-induced sepsis when administered at a dose of 15 mg/kg.{57868}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 5 mg, 500 µg |
|---|---|
| Shipping | dry ice |
| CAS number | 26441-05-4 |
| Molecular formula | C20H30O5 |
| Smiles | O[C@H]1[C@H](/C=C/C(CCCCC)=O)[C@@H](C/C=CCCCC(O)=O)C(C1)=O, O[C@H]1[C@H](/C=C/C(CCCCC)=O)[C@@H](C/C=CCCCC(O)=O)C(C1)=O, O[C@H]1[C@H](/C=C/C(CCCCC)=O)[C@@H](C/C=CCCCC(O)=O)C(C1)=O, O[C@H]1[C@H](/C=C/C(CCCCC)=O)[C@@H](C/C=CCCCC(O)=O)C(C1)=O |
| Molecular weight | 350,5 |
| Custom code | 2937.50 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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ISO/IEC 17025:2005
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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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