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Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.{8838} Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2?. 15-keto-17-phenyl trinor PGF2? is a potential metabolite of bimatoprost when administered to animals. 15-keto PG analogs are potential minor impurities in commercial preparations of their corresponding bulk drug compounds. Although much less potent that the parent compound, 15-keto PGs still retain the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 µg/eye.{1107} 15-keto Latanoprost (15-keto-17-phenyl-13,14-dihydro trinor PGF2? isopropyl ester) is a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 µg/eye. Again, this is not as potent as many other F-type PGs; for example, PGF2? will produce this degree of miosis at a dose of less than 1 µg/eye.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 949564-89-0 |
| Molecular formula | C23H30O5 |
| Smiles | O[C@@H]1[C@H](C/C=CCCCC(O)=O)[C@@H](/C=C/C(CCC2=CC=CC=C2)=O)[C@H](O)C1, O[C@@H]1[C@H](C/C=CCCCC(O)=O)[C@@H](/C=C/C(CCC2=CC=CC=C2)=O)[C@H](O)C1, O[C@@H]1[C@H](C/C=CCCCC(O)=O)[C@@H](/C=C/C(CCC2=CC=CC=C2)=O)[C@H](O)C1 |
| Molecular weight | 386,5 |
| Custom code | 2937.50 |
| Formulation | A solution in methyl acetate |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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