€724.00 €615.40
15-hydroxy Prostaglandin dehydrogenase (PGDH) is an enzyme of the short-chain alcohol dehydrogenase family that catalyzes the oxidation of prostaglandins to 15-keto metabolites with reduced biological activity.{8277,5201,340,55499} It uses NAD+ as a cofactor and, in addition to PGs, also converts various hydroxy fatty acids, such as HETEs, resolvins, and lipoxins, to less active keto metabolites.{55499,6339,15718,55500,55501} 15-PGDH acts as a tumor suppressor, and restoring HPGD, the gene encoding 15-PGDH, expression in human colon cancer cells in vitro reduces subsequent tumor formation in mouse xenograft models.{14568,14566,12480,18885} Knockout of Hpgd or inhibition of 15-PGDH in mice increases hepatic tissue regeneration and induces resistance to ulcerative colitis.{29053} Inhibition of 15-PGDH also increases mitochondrial function and autophagic flux in muscle tissue, as well as increases muscle mass and strength in aged mice.{59739} Cayman’s 15-PGDH D50H variant (human, recombinant) protein contains an aspartate-to-histidine substitution at position 50 (D50H) and can be used for enzyme assay and Western blot (WB) applications.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Formulation | 50 mM potassium phosphate, pH 7.6, with 150 mM sodium chloride, 1 mM EDTA, 0.1 mM DTT, and 5% glycerol |
| Purity | ≥90% estimated by SDS-PAGE |
| Custom code | 3507.90 |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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