15-deoxy-Δ12,14-Prostaglandin J2

15-deoxy-Δ12,14-Prostaglandin J2

CAT N°: 18570
Price:

From 48.00 40.80

15-deoxy-Δ12,14-Prostaglandin J2 (15-deoxy-Δ12,14-PGJ2) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 µM in a murine chimera system.{1428,1424} 15-deoxy-Δ12,14-PGJ2 is more potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.{1428}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 11-oxo-prosta-5Z,9,12E,14E-tetraen-1-oic acid
  • Correlated keywords
    • PPAR? PPARgamma prostaglandins 15-deoxy-delta12,14-PGJ2 15-deoxy-d12,14-PGJ2 nuclear receptors 15-deoxy-?12,14-PGJ2 peroxisome proliferator-activated receptors PPARs activators ligands 15dpgj2 atherosclerosis
  • Product Overview:
    15-deoxy-Δ12,14-Prostaglandin J2 (15-deoxy-Δ12,14-PGJ2) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 µM in a murine chimera system.{1428,1424} 15-deoxy-Δ12,14-PGJ2 is more potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.{1428}

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