1,4-Benzo<wbr/>quinone

1,4-Benzoquinone

CAT N°: 27560
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1,4-Benzoquinone is a toxic metabolite of benzene.{47532} It is formed via hepatic metabolism of benzene to 1,4-hydroquinone followed by myeloperoxidase processing of 1,4-hydroquinone in bone marrow.{47533} 1,4-Benzoquinone decreases levels of cytochrome P450 in a concentration-dependent manner in minipig liver microsomes.{47532} It induces DNA mutations in human W138-VA13 and mouse HL18 cells.{47534} 1,4-Benzoquinone (10 and 20 ?M) disrupts mitochondrial membrane potential and reduces viability, increases production of reactive oxygen species (ROS), and induces apoptosis in a concentration-dependent manner in HL-60 cells.{47535}

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