13,14-dihydro-15-keto Prostaglandin D<sub>2</sub>-d<sub>9</sub>

13,14-dihydro-15-keto Prostaglandin D2-d9

CAT N°: 19334
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263.00 223.55

13,14-dihydro-15-keto-Prostaglandin D2-d9 (13,14-dihydro-15-keto PGD2-d9) is intended for use as an internal standard for the quantification of 13,14-dihydro-15-keto PGD2 (Item No. 12610) by GC- or LC-MS. 13,14-dihydro-15-keto PGD2 is a metabolite of PGD2 (Item No. 12010) which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD2 was recently identified as a selective agonist for the CRTH2/DP2 receptor.{5248} It also inhibits ion flux in a canine colonic mucosa preparation.{9769} In humans, 13,14-dihydro-15-keto PGD2 is further metabolized to give 11?-hydroxy compounds which have also undergone ?-oxidation of one or both side chains. Virtually no 13,14-dihydro-15-keto PGD2 survives intact in the urine.{418,35}

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