1,3-Di-<em>o</em>-<wbr/>tolylguanidine

1,3-Di-o–tolylguanidine

CAT N°: 31736

1,3-Di-o-tolylguanidine (DTG) is a sigma (?) receptor ligand (Kis = 61 and 42 nM for ?1 and ?2 receptors, respectively).{54533} In vivo, DTG (10, 15, and 20 mg/kg, i.p.) increases latency to tail withdrawal in the tail flick test and induces hypothermia in mice.{54534} It decreases infarct size and increases the number of cortical and hippocampal NeuN-positive neurons in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{54535}

Territorial Availability: Available through Bertin Technologies only in France

Technical Warning: Bertin Technologies restricts the sale of this product to licensed controlled substance laboratories and qualified academic research institutions. Please contact us for further details.

Special Advice: Dangerous Good in said quantity, not available for sale.

  • Synonyms
    • N,N?-bis(2-methylphenyl)-guanidine
  • Correlated keywords
    • 46913-50-2 60297-72-5 132116-33-7 NSC132023 NSC473 akrochem vulcafor vulkacit eveite rhenogran DOTG 70 nocceler sanceler soxinol DT
  • Product Overview:
    1,3-Di-o-tolylguanidine (DTG) is a sigma (?) receptor ligand (Kis = 61 and 42 nM for ?1 and ?2 receptors, respectively).{54533} In vivo, DTG (10, 15, and 20 mg/kg, i.p.) increases latency to tail withdrawal in the tail flick test and induces hypothermia in mice.{54534} It decreases infarct size and increases the number of cortical and hippocampal NeuN-positive neurons in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{54535}

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