12-PAHSA-d₃₁

Territorial Availability: Available through Bertin Technologies only in France

• Synonyms
  • 12-[(1-oxohexadecyl)oxy]-octadecanoic-2,2′,3,3′,4,4′,5,5′,6,6′,7,7′,8,8′,9,9′,10,10′,11,11′,12,12′,13,13′,14,14′,15,15′,16,16,16-d31 acid
• Correlated keywords
  • biochemical inflammation metabolic syndrome obesity lipid fatty acid metabolism type 2 diabetes insulin resistance branched ester hydroxy FAHFA hydroxyl anti-diabetic endogenous insensitivity C-16 C-18 substituent palmitic esterified 12-hydroxy stearic elevated serum glucose tolerance tolerant AG4OX adipose-specific overexpression mice mouse fasted wild-type high-fat diet-induced Glu4 transporter tissue resistant deuterated deuterium internal quantifies quantify quantification GC-MS GC/MS gas chromatography mass spectrometry LC-MS LC/MS liquid isotope
• Product Overview:
  12-PAHSA-d31 contains 31 deuterium atoms at the 2, 2′, 3, 3′, 4, 4′, 5, 5′, 6, 6′, 7, 7′, 8, 8′, 9, 9′, 10, 10′, 11, 11′, 12, 12′, 13, 13′, 14, 14′, 15, 15′, 16, 16, and 16 positions. It is intended for use as an internal standard for the quantification of 12-PAHSA by GC- or LC-mass spectrometry. Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity.{27644} Structurally, these esters are comprised of a C-16 or C-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid) linked to either a C-16 or C-18 hydroxy substituent. 12-PAHSA is a FAHFA in which palmitic acid is esterified on the 12th carbon of hydroxy stearic acid. Among the FAHFA family members, PAHSAs are the most abundant in the adipose tissue of glucose tolerant AG4OX mice, which overexpress the Glut4 glucose transporter specifically in adipose tissue.{27644} 12-PAHSA is present at 2- to 3-fold higher levels in adipose tissue of AG4OX mice compared to wild type mice.{27644} Levels of 12-PAHSA are also higher in fasted wild-type mice compared to fed mice and are reduced upon high-fat diet-induced obesity in insulin-resistant mice.{27644}