12-OAHSA-d<sub>17</sub>

12-OAHSA-d17

CAT N°: 17195
Price:

From 122.00 103.70

12-OAHSA-d17 contains 17 deuterium atoms at the 11, 11′, 12, 12′, 13, 13′, 14, 14′, 15, 15′, 16, 16′, 17, 17′, 18, 18, and 18 positions. It is intended for use as an internal standard for the quantification of 12-OAHSA by GC- or LC-mass spectrometry. Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity.{27644} Structurally, these esters are comprised of a C-16 or C-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid) linked to either a C-16 or C-18 hydroxy substituent. 12-OAHSA is a FAHFA in which oleic acid is esterified at the 12th carbon of hydroxy stearic acid. Among the FAHFA family members, OAHSAs are the most abundantly expressed in the serum of glucose tolerant AG4OX mice, which overexpress the Glut4 glucose transporter specifically in adipose tissue.{27644}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 11-carboxy-1-hexylundecyl ester-9Z-octadecenoic-11,11′,12,12′,13,13′,14,14′,15,15′,16,16′,17,17′,18,18,18-d17 acid
  • Correlated keywords
    • Biochemical inflammation metabolic syndrome obesity lipid fatty acid metabolism type 2 diabetes insulin resistance branched ester hydroxy FAHFA hydroxyl anti-diabetic endogenous insensitivity C-16 C-18 substituent oleic esterified 12-hydroxy stearic elevated serum glucose tolerance tolerant AG4OX adipose-specific overexpression mice mouse Glu4 transporter tissue deuterated deuterium internal quantifies quantify quantification GC-MS GC/MS gas chromatography mass spectrometry LC-MS LC/MS liquid isotope
  • Product Overview:
    12-OAHSA-d17 contains 17 deuterium atoms at the 11, 11′, 12, 12′, 13, 13′, 14, 14′, 15, 15′, 16, 16′, 17, 17′, 18, 18, and 18 positions. It is intended for use as an internal standard for the quantification of 12-OAHSA by GC- or LC-mass spectrometry. Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity.{27644} Structurally, these esters are comprised of a C-16 or C-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid) linked to either a C-16 or C-18 hydroxy substituent. 12-OAHSA is a FAHFA in which oleic acid is esterified at the 12th carbon of hydroxy stearic acid. Among the FAHFA family members, OAHSAs are the most abundantly expressed in the serum of glucose tolerant AG4OX mice, which overexpress the Glut4 glucose transporter specifically in adipose tissue.{27644}

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