10Z-<wbr/>Hymenialdisine

10Z-Hymenialdisine

CAT N°: 14198
Price:

€314.00 €266.90

10Z-Hymenialdisine is a natural marine sponge alkaloid with numerous cellular actions. Most notably, it blocks signaling through the Raf-1/MEK-1/MAPK pathway by potently inhibiting MEK-1 (IC50 = 9 nM).{24027} Hymenialdisine also inhibits numerous kinases in vitro, most notably GSK3?, CDK1/cyclin B, CDK5/p25, CK1, and CDK2/cyclin E (IC50s = 10, 22, 28, 35, and 40 nM, respectively), as well as, less potently, ERK1/2 and several isoforms of PKC.{28027,24024} Early studies demonstrated that it suppresses inflammatory gene expression by blocking signaling through NF-?B at micromolar concentrations.{28028} At similar concentrations, hymenialdisine also blocks bacterial quorum sensing.{28029}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (4Z)-4-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-2-bromo-4,5,6,7-tetrahydro-pyrrolo[2,3-c]azepin-8(1H)-one
  • Correlated keywords
    • biochemical natural product inhibitor cell cycle intracellular signaling quorum sensing inflammation NF-kB kinase protein Alzheimer’s disease 84094-93-9 alkaloid inhibit MEK-1 MEK1 10ZHymenialdisine marine sponge alkaloid cellular Raf-1/MEK-1/MAPK pathway Raf-1 MEK-1 MAPK in vitro GSK3? CDK1/cyclin B CDK5/p25 CK1 CDK2/cyclin E ERK1/2 PKC suppress inflammatory gene expression bacterial
  • Product Overview:
    10Z-Hymenialdisine is a natural marine sponge alkaloid with numerous cellular actions. Most notably, it blocks signaling through the Raf-1/MEK-1/MAPK pathway by potently inhibiting MEK-1 (IC50 = 9 nM).{24027} Hymenialdisine also inhibits numerous kinases in vitro, most notably GSK3?, CDK1/cyclin B, CDK5/p25, CK1, and CDK2/cyclin E (IC50s = 10, 22, 28, 35, and 40 nM, respectively), as well as, less potently, ERK1/2 and several isoforms of PKC.{28027,24024} Early studies demonstrated that it suppresses inflammatory gene expression by blocking signaling through NF-?B at micromolar concentrations.{28028} At similar concentrations, hymenialdisine also blocks bacterial quorum sensing.{28029}

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