10,11-dihydro-10-hydroxy Carbamazepine

10,11-dihydro-10-hydroxy Carbamazepine

CAT N°: 18467
Price:

From 75.00 63.75

10,11-dihydro-10-hydroxy Carbamazepine is the active metabolite of oxcarbazepine (Item No. 17340). Oxcarbazepine is rapidly and almost completely converted to 10,11-dihydro-10-hydroxycarbamazepine, which then demonstrates anticonvulsant efficacy by modulating several ion channels and receptors.{25311,25313} 10,11-dihydro-10-hydroxy Carbamazepine is reported to inhibit both voltage-gated Na+ and Ca2+ channels, to potentiate voltage-gated K+ channels, to antagonize adenosine A1 receptors, to increase dopaminergic transmission, and to inhibit glutamate release.{25311}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
  • Correlated keywords
    • metabolite BIA2-005 BIA2005 voltage-gated Na+ Ca2 K+ antiepileptic GP47779
  • Product Overview:
    10,11-dihydro-10-hydroxy Carbamazepine is the active metabolite of oxcarbazepine (Item No. 17340). Oxcarbazepine is rapidly and almost completely converted to 10,11-dihydro-10-hydroxycarbamazepine, which then demonstrates anticonvulsant efficacy by modulating several ion channels and receptors.{25311,25313} 10,11-dihydro-10-hydroxy Carbamazepine is reported to inhibit both voltage-gated Na+ and Ca2+ channels, to potentiate voltage-gated K+ channels, to antagonize adenosine A1 receptors, to increase dopaminergic transmission, and to inhibit glutamate release.{25311}

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