1-<wbr/>Stearoyl-<wbr/>2-<wbr/>Arachidonoyl-<wbr/><em>sn</em>-<wbr/>Glycerol

1-Stearoyl-2-Arachidonoyl-sn–Glycerol

CAT N°: 10008650
Price:

From 75.00 63.75

Many protein kinase C (PKC) isoforms require activation via second messengers including Ca2+, diacylglycerol (DAG), and/or a phospholipid to phosphorylate target proteins and they initiate a variety of important signalling cascades.{943} 1-Stearoyl-2-arachidonoyl-sn-glycerol (SAG) is a DAG that contains the ?-6 polyunsaturated fatty acid arachidonic acid in the sn-2 position and stearic acid in the sn-1 position of the glycerol backbone. It can potently activate PKC?, PKC?, and PKC? at nM concentrations.{15530} Independent of PKC signalling, SAG competitively binds to the Ras activator RasGRP with a Ki value of 4.49 µM in Jurkat T-cells.{15529}

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