24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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1-NA-PP1 is a reversible, cell-permeable inhibitor of Src-family tyrosine kinases that have been mutated, by a single base substitution, to become ‘analog sensitive’ (as), as compared to the wild-type kinase. 1-NA-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 1.5 nM versus 1.0 ?M, respectively).{17286} The homologous mutation in other kinases generated similar analog sensitivity (e.g., IC50 = 1.5 nM for c-Fyn-as1 versus 0.6 ?M for c-Fyn; 7.0 nM for c-Abl-as2 versus 0.6 ?M for c-Abl; 15 nM for Cdk2-as1 versus 18 ?M for Cdk2).{17287} This approach has been used to elucidate functions of several kinases in both mammalian and yeast systems.{17287,20028,20029}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 5 mg, 50 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 221243-82-9 |
| Molecular formula | C19H19N5 |
| Smiles | NC1=C(C(C2=C(C=CC=C3)C3=CC=C2)=NN4C(C)(C)C)C4=NC=N1 |
| Molecular weight | 317,4 |
| Custom code | 2933.49 |
| Formulation | A crystalline solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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