1-Methylpseudouridine

1-Methylpseudouridine

CAT N°: 35401
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From 66.00 56.10

1-Methylpseudouridine is a nucleoside analog that has been found in Streptomyces platensis.{65154} It increases the thermodynamic and biological stability of RNA.{65155,65156,65157} Unlike unmodified mRNA, 1-methylpseudouridine-containing mRNA does not induce IFN-? secretion in A549 cells, indicating low immunogenicity.{65156} Intramuscular or intradermal administration of luciferase mRNA containing 1-methylpseudouridine via lipid complexes increases luciferase activity in mice. Formulations containing 1-methylpseudouridine incorporated into mRNA have been used in the development of mRNA-based vaccines.

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