1-Aminocyclo<wbr/>propane<wbr/>carboxylic Acid

1-Aminocyclopropanecarboxylic Acid

CAT N°: 16132
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From €48.00 €40.80

1-Aminocyclopropanecarboxylic acid (ACPC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence.{26310} ACPC has been shown to modulate NMDA receptor activity by acting as a partial agonist at the glycine-binding site on NMDA receptors (EC50 = 0.7-0.9 µM) in the presence of low levels (1 µM) of glutamate and as a competitive antagonist at the glutamate-binding site on NMDA receptors (EC50 = 81.6 nM) with high levels (10 µM) of glutamate.{26311} This compound has been reported to protect against neuron cell death in in vivo models of ischemia by enabling moderate levels of NMDA receptor activation and attenuating any excess NMDA receptor signaling that may lead to neurotoxicity.{26311}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1-amino-cyclopropanecarboxylic acid
  • Correlated keywords
    • ethylene biosynthesis plants biology strokes traumatic brains injury injuries NMDA receptors antagonists glycine-binding glycines binding binds sites partial agonists neuroprotective ischemia glutamate-binding glutamate intermediates synthesis competitive neuron cells death neurosciences growth regulators regulates biochemistry 1-amino-1-carboxycyclopropane 1-aminocyclopropane-1-carboxylate 1-aminocyclopropane-1-carboxylic acids 1-aminocyclopropanecarboxylic NSC98430 NSC-98430 a-aminocyclopropanecarboxylic .alpha.-aminocyclopropanecarboxylic alpha-aminocyclopropanecarboxylic a-aminocyclopropanecarboxylic
  • Product Overview:
    1-Aminocyclopropanecarboxylic acid (ACPC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence.{26310} ACPC has been shown to modulate NMDA receptor activity by acting as a partial agonist at the glycine-binding site on NMDA receptors (EC50 = 0.7-0.9 µM) in the presence of low levels (1 µM) of glutamate and as a competitive antagonist at the glutamate-binding site on NMDA receptors (EC50 = 81.6 nM) with high levels (10 µM) of glutamate.{26311} This compound has been reported to protect against neuron cell death in in vivo models of ischemia by enabling moderate levels of NMDA receptor activation and attenuating any excess NMDA receptor signaling that may lead to neurotoxicity.{26311}

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