γ-Mangostin

CAT N°: 26675

Price:

From ~~€185.00~~ €157.25

γ-Mangostin is a xanthone that has been found in G. mangostana and has diverse biological activities.{48253,48254,48255,48256} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in vitro with an IC50 value of 23.6 μM.{48253} γ-Mangostin is cytotoxic to HL-60, SMMC-7721, A549, MCF-7, and SW480 cancer cells and BEAS-2B non-cancerous pulmonary epithelial cells in vitro (IC50s = 7.39, 6.57, 10.07, 5.33, 8.4, and 7.43 μM, respectively).{48254} It inhibits LPS-induced expression of IL-6, IL-10, and TNF-α in human macrophages in a concentration-dependent manner.{48255} Macrophage-conditioned media from macrophages pre-incubated with γ-mangostin (30 μM) prior to stimulation with LPS has a reduced ability to induce inflammation and insulin resistance in primary human adipocytes. γ-Mangostin (5 and 10 mg/kg) inhibits carbon tetrachloride-induced increases in serum levels of aspartate transaminase (AST) and alanine aminotransferase (ALT) and decreases in hepatic superoxide dismutase 2 (SOD2) activity and glutathione (GSH) content in a mouse model of liver fibrosis.{48256}

Product overview

Data

Downloads

About Cayman

Product overview

Territorial Availability: Available through Bertin Technologies only in France

Synonyms
- 1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
Correlated keywords
- γMangostin garcinia HL60 SMMC7721 A 549 MCF7 SW 480 BEAS2B 2 B noncancerous lipopolysaccharide IL6 IL10 TNF? interleukin tumor necrosis factor preincubated SOD demethylmangostin 7-O-Demethyl-?-mangostin Normangostin
Product Overview:
γ-Mangostin is a xanthone that has been found in G. mangostana and has diverse biological activities.{48253,48254,48255,48256} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in vitro with an IC50 value of 23.6 μM.{48253} γ-Mangostin is cytotoxic to HL-60, SMMC-7721, A549, MCF-7, and SW480 cancer cells and BEAS-2B non-cancerous pulmonary epithelial cells in vitro (IC50s = 7.39, 6.57, 10.07, 5.33, 8.4, and 7.43 μM, respectively).{48254} It inhibits LPS-induced expression of IL-6, IL-10, and TNF-α in human macrophages in a concentration-dependent manner.{48255} Macrophage-conditioned media from macrophages pre-incubated with γ-mangostin (30 μM) prior to stimulation with LPS has a reduced ability to induce inflammation and insulin resistance in primary human adipocytes. γ-Mangostin (5 and 10 mg/kg) inhibits carbon tetrachloride-induced increases in serum levels of aspartate transaminase (AST) and alanine aminotransferase (ALT) and decreases in hepatic superoxide dismutase 2 (SOD2) activity and glutathione (GSH) content in a mouse model of liver fibrosis.{48256}

Data

Size	10 mg, 25 mg, 5 mg, 50 mg
Shipping	dry ice
CAS Number	31271-07-5
Molecular Formula	C23H24O6
SMILES	OC1=C2C(OC(C=C(O)C(O)=C3C/C=C(C)/C)=C3C2=O)=CC(O)=C1C/C=C(C)/C
Molecular Weight	396,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2907.29
UNSPSC code	12352100

Downloads

About Cayman

We also advise you

Globosuxanthone A

Globosuxanthone A is a fungal metabolite originally isolated from C. globosum.{48211} It is cytotoxic to various human solid tumor cell...

View

Mangiferin

Mangiferin is a xanthone glucoside that has been found in M. indica with diverse biological activities.{37665} It increases survival of...

View

β-Mangostin

β-Mangostin is a xanthone originally isolated from G. mangostana with diverse biological activites.{39821,39822,39823,39824,39825,39826} It inhibits growth of methicillin-resistant S. aureus...

€365.00 – €2,185.00

View

Albofungin

Albofungin is a xanthone isolated from A. tumemacerans with diverse biological activities.{41087,41088} It inhibits the growth of various Gram-positive bacteria...

View