Rimegepant
Rimegepant
Rimegepant is an orally bioavailable antagonist of the calcitonin gene-related peptide (CGRP) receptor (Ki = 0.027 nM).{47524} It inhibits cAMP...
ViewPrice:
From €285.00 €242.25
From €285.00 €242.25
β-Calcitonin gene-related peptide (β-CGRP) is a neuropeptide with roles in vasodilation, cardiovascular regulation, and inflammation.{41395} It belongs to the calcitonin family of peptides, which also includes α-CGRP (Item Nos. 24405
24728), amylin (Item No. 24274), calcitonin (Item Nos. 24409
24410), and adrenomedullin.{38633} β-CGRP binds selectively to a heteromeric complex of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1; IC50 = 0.01 nM) over a complex of CLCR and RAMP2 (IC50 = 300 nM).{41396} It binds to rat brain and spleen membrane preparations (IC50s = 1.1 and 1 nM, respectively) and relaxes human cerebral and middle meningeal arterial segments precontracted with prostaglandin F2α (PGF2α; Item No. 16010; IC50s = 0.38 and 4.9 nM, respectively).{38809,41528} In vivo, β-CGRP induces a 50% increase in diameter of arterioles precontracted with human endothelin-1 (ET-1; Item No. 24127) in hamster cheek pouch at a concentration of 15.8 pM.{41529}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 500 µg |
|---|---|
| Shipping | dry ice |
| Molecular formula | C162H267N51O48S3 • XCF3COOH |
| SMILES | NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@H](CO)NC(CNC([C@H](C(C)C)NC([C@H](CC(N)=O)NC([C@@]([C@@H](C)O)([H])NC([C@@H]1CCCN1C([C@H](C(C)C)NC([C@@H](NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@@H](NC(CNC(CNC([C@H](CO)NC([C@H](CCCNC(N)=N |
| Molecular Weight | 3793,4 |
| Formulation | A lyophilized powder |
| Purity | ≥95% |
| Custom Code | 3504.00 |
| UNSPSC code | 12352100 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
Rimegepant is an orally bioavailable antagonist of the calcitonin gene-related peptide (CGRP) receptor (Ki = 0.027 nM).{47524} It inhibits cAMP...
View
Amylin is a peptide hormone secreted from pancreatic ?-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and...
View
Tyr-?-CGRP is an N-terminal extended tyrosinated analogue of ?-calcitonin gene-related peptide (?-CGRP; Item No. 24405).{38807} It binds to amylin receptors...
Calcitonin is a peptide hormone that lowers blood calcium level and inhibits bone resorption.{38632,39431} It belongs to the calcitonin family...
Tyr-β-CGRP is an N-terminal extended tyrosinated analog of β-calcitonin gene-related peptide (β-CGRP; Item No. 24725).
Amylin (8-37) is a peptide fragment of amylin (Item Nos. 24274 | 24275).{41819} It inhibits osteoblast proliferation, but not bone...
Amylin is a 37-residue peptide hormone secreted from pancreatic ?-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying,...
?-Calcitonin gene-related peptide (?-CGRP) is a neuropeptide with roles in vasodilation, cardiovascular regulation, and inflammation.{41395} It belongs to the calcitonin...
View
Adrenomedullin (1-52) is a peptide with diverse biological activities.{39625,39626,39627,39628} It belongs to the calcitonin family of peptides, which includes amylin...
Headquarters:
Parc d’activités du Pas du Lac
10 bis avenue Ampère
78180 Montigny le Bretonneux
France
Copyright © 2024 BERTIN BIOREAGENT. All rights reserved | Terms & conditions
