(±)10(11)-EDP Ethanolamide

(±)10(11)-EDP Ethanolamide

CAT N°: 25878
Price:

From 134.00 113.90

(±)10(11)-EDP ethanolamide is an ?-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 0.43 and 22.5 nM for CB1 and CB2 receptors, respectively).{42488} It is produced though direct epoxygenation of docosahexaenoyl ethanolamide (DHEA; Item No. 10007534) by cytochrome P450 (CYP) epoxygenases.{42488,40186} 10,11-EDP epoxide (12.5 and 25 ?M) reduces the viability of 143B metastatic osteosarcoma cells.{42488} It induces apoptosis and inhibits cell migration in a wound-healing assay in 143B, MG63, and HOS osteosarcoma cells. (±)10(11)-EDP ethanolamide also reduces tube formation by human umbilical vein endothelial cells (HUVECs) in a Matrigel™ assay.

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