(±)-<wbr/>SKF 81297 (hydro<wbr>bromide)

(±)-SKF 81297 (hydrobromide)

CAT N°: 15067
Price:

From €146.00 €124.10

(±)-SKF 81297 is a selective agonist of the dopamine D1-like receptor (Ki = 1.9 nM).{24103} It demonstrates comparatively lower binding affinity for the dopamine D2, dopamine D3, serotonin 5-HT2A, and adrenergic ?2 receptors (Kis = 1,272, >10,000, 955, and 509 nM, respectively).{24103} Activation of dopamine D1-like receptors by selective agonists such as (±)-SKF 81297 have been implicated in initiating a cascade of signaling events leading to reward-related incentive learning.{24104}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 6-?chloro-?2,?3,?4,?5-?tetrahydro-?1-?phenyl-1H-?3-?benzazepine-?7,?8-?diol, monohydrobromide
  • Correlated keywords
    • 71636-61-8 agonists dopamines D1-like D1 likes receptors rewards related reward-related incentives learning neurosciences SKFs 81297 SKF-81297 SKF81297 signaling learn signals selectives binding affinity serotonin-2A serotonin 2A 2 A D 1 2 3 D2 D3 adrenergic ?2 ? 2 alpha2 .alpha.2 activations cascades events
  • Product Overview:
    (±)-SKF 81297 is a selective agonist of the dopamine D1-like receptor (Ki = 1.9 nM).{24103} It demonstrates comparatively lower binding affinity for the dopamine D2, dopamine D3, serotonin 5-HT2A, and adrenergic ?2 receptors (Kis = 1,272, >10,000, 955, and 509 nM, respectively).{24103} Activation of dopamine D1-like receptors by selective agonists such as (±)-SKF 81297 have been implicated in initiating a cascade of signaling events leading to reward-related incentive learning.{24104}

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