24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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€270.00 €229.50
(±)-Nebivolol-d4 is intended for use as an internal standard for the quantification of nebivolol (Item No. 23660) by GC- or LC-MS. Nebivolol is an antagonist of the ?1-adrenergic receptor (?1-AR; IC50 = 7.41 nM).{38519} It is selective for ?1- over ?2-ARs (IC50 = 251 nM), as well as the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT2 and the ?1- and ?2-adrenergic, histamine H1, and dopamine D2 receptors (IC50s = 27.5, 2,239, 3,162, >10,000, 5,623, and 10,000 nM, respectively). Nebivolol induces vasodilation in isolated mouse renal arteries (EC50 = 11.36 ?M) and decreases contraction of isolated human left ventricular trabeculae induced by isoproterenol (Item No. 15592; IC50 = 7 ?M).{38521,38522} Nebivolol inhibits proliferation of primary human coronary artery smooth muscle cells (HCASMCs) in the presence and absence of growth factors (IC50s = 6.1, 6.8, 6.4, and 7.7 ?M for HCASMCs grown in media containing no growth factor, PDGF-BB, basic FGF, and TGF-?1, respectively).{38523} It is also an inhibitor of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), also known as 3C-like protease (3CLpro; IC50 = 60.2 µg/ml), and inhibits SARS-CoV-2 pathogenicity in vitro (IC50 = 0.03 µg/ml).{64706} Formulations containing nebivolol have been used in the treatment of hypertension.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg |
|---|---|
| Shipping | dry ice |
| Molecular formula | C22H21D4F2NO4 • HCl |
| Smiles | FC1=CC=C2C(CCC(C(O)C([2H])([2H])NC([2H])([2H])C(O)C3CCC(C=C(F)C=C4)=C4O3)O2)=C1.Cl |
| Molecular weight | 445,9 |
| Formulation | A solid |
| Purity | ≥99% deuterated forms (d1-d4) |
| Custom code | 3822.19 |
| UNSPSC code | 12352100 |
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