(±)-N-desmethyl Venlafaxine (hydrochloride)

(±)-N-desmethyl Venlafaxine (hydrochloride)

CAT N°: 35403
Price:

From 48.00 40.80

(±)-N-desmethyl Venlafaxine is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine.{65180} It is formed from venlafaxine by the cytochrome P450 (CYP) isoform CYP3A4.{32155} (±)-N-desmethyl Venlafaxine inhibits norepinephrine and serotonin reuptake in rat synaptosome preparations (IC50s = 4.7 and 1.6 µM, respectively).{65180} In vivo, (±)-N-desmethyl venlafaxine reverses reserpine-induced hypothermia in mice with a minimum effective dose (MED) of 10 mg/kg.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 1-[1-(4-methoxyphenyl)-2-(methylamino)ethyl]-cyclohexanol, monohydrochloride
  • Correlated keywords
    • 130198-38-8 149289-30-5 Wy45494 CYP450 CYP-450 3A4 P-450 anti-depressant desmethylvenlafaxine
  • Product Overview:
    (±)-N-desmethyl Venlafaxine is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine.{65180} It is formed from venlafaxine by the cytochrome P450 (CYP) isoform CYP3A4.{32155} (±)-N-desmethyl Venlafaxine inhibits norepinephrine and serotonin reuptake in rat synaptosome preparations (IC50s = 4.7 and 1.6 µM, respectively).{65180} In vivo, (±)-N-desmethyl venlafaxine reverses reserpine-induced hypothermia in mice with a minimum effective dose (MED) of 10 mg/kg.

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