(±)-N-desmethyl Venlafaxine (hydrochloride)

(±)-N-desmethyl Venlafaxine (hydrochloride)

CAT N°: 35403
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48.00 40.80

(±)-N-desmethyl Venlafaxine is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine.{65180} It is formed from venlafaxine by the cytochrome P450 (CYP) isoform CYP3A4.{32155} (±)-N-desmethyl Venlafaxine inhibits norepinephrine and serotonin reuptake in rat synaptosome preparations (IC50s = 4.7 and 1.6 µM, respectively).{65180} In vivo, (±)-N-desmethyl venlafaxine reverses reserpine-induced hypothermia in mice with a minimum effective dose (MED) of 10 mg/kg.

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